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KMID : 0380620140460030358
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Korean Journal of Food Science and Technology
2014 Volume.46 No. 3 p.358 ~ p.363
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Effects of the KI-180 and KI-188 Calcium Formulae on the Growth and Development of Rats
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Park Seung-Man
Seong Ki-Seung
Lee Jong-Seok
Lee Ok-Hwan
Han Chan-Kyu
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Abstract
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Herbs have active components that promote the growth rate of both animals and human. The KI-180 and KI- 188 calcium food formulae contain Acanthopanacis cortex, Bombysis corpus and hoelen, seaweed calcium, chlorella extract, spirulina, colostrum powder, and other natural and functional components. We evaluated the growth-promoting effects of these formulae by analyzing the weight, femur and backbone, alkaline phosphatase, osteocalcin, testosterone, insulin-like growth factor (IGF)-1, and IGF binding protein-3 (IGFBP-3) of growing rats. Growing rats administered with KI-180 and KI-188 calcium showed the increase of body weight, body length, and femur weight and length of growing rats. In addition, administration of KI-180 and KI-188 calcium increased the alkaline phosphatase activity, the levels of osteocalcin and the growth hormones IGF-1 and IGFBP-3 of growing rats. The impact of KI-180 and KI-188 calcium on the physical development of growing rats suggests that the incorporation of these food formulae in the diets of growing children may promote the physical development.
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KEYWORD
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KI-180, growth hormone, IGF-1, IGFBP-3
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